About
Dr. Dean Sherzai is a behavioral neurologist, scientist, and global health leader whose career spans clinical neurology, epidemiology, implementation science, health-system design, and international development. He is recognized for developing large-scale, evidence-based models that improve brain health, strengthen healthcare systems, and empower communities.
At Ƶ (Ƶ), Dr. Sherzai serves as Executive Director of Clinical Research, Director of the Community Core of the Clinical & Translational Research Institute, and Professor of Neurology & Neuroscience. His work at Ƶ centers on community-based clinical trials, cognitive and vascular aging, lifestyle interventions, digital behavior-change tools, and health equity driven research.
A key initiative under his leadership is the INSPIRE Project, housed within Ƶ’s Community Core. INSPIRE is a lifestyle-intervention program, uniting longitudinal data, culturally grounded health education, precision behavioral modeling, and deep community partnership. It represents a transformational national model for reducing cognitive decline and improving vascular and metabolic health at scale.
Research Interests
- Neurodegenerative diseases: Alzheimer’s, vascular dementia, mixed dementias
- Lifestyle and precision prevention at the community and population level
- Behavior change, habit formation, and neural mechanisms of resilience
- Prospective lifestyle-intervention models and implementation science
- Digital health and AI-driven behavioral support systems
- Social determinants, health equity, and community-led research
- Longitudinal and multi-site cohort studies in underserved populations