About

Dr. Dean Sherzai is a behavioral neurologist, scientist, and global health leader whose career spans clinical neurology, epidemiology, implementation science, health-system design, and international development. He is recognized for developing large-scale, evidence-based models that improve brain health, strengthen healthcare systems, and empower communities.

At Ƶ (Ƶ), Dr. Sherzai serves as Executive Director of Clinical Research, Director of the Community Core of the Clinical & Translational Research Institute, and Professor of Neurology & Neuroscience. His work at Ƶ centers on community-based clinical trials, cognitive and vascular aging, lifestyle interventions, digital behavior-change tools, and health equity driven research.

A key initiative under his leadership is the INSPIRE Project, housed within Ƶ’s Community Core. INSPIRE is a lifestyle-intervention program, uniting longitudinal data, culturally grounded health education, precision behavioral modeling, and deep community partnership. It represents a transformational national model for reducing cognitive decline and improving vascular and metabolic health at scale.

Research Interests

  • Neurodegenerative diseases: Alzheimer’s, vascular dementia, mixed dementias
  • Lifestyle and precision prevention at the community and population level
  • Behavior change, habit formation, and neural mechanisms of resilience
  • Prospective lifestyle-intervention models and implementation science
  • Digital health and AI-driven behavioral support systems
  • Social determinants, health equity, and community-led research
  • Longitudinal and multi-site cohort studies in underserved populations